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May refine regenerative strategies via maturation biomarkers; leaves open clinical translation pending validation.
Abstract figure legend In the mammalian fetal (immature) heart, cardiomyocytes proliferate and can regenerate in a low-oxygen environment. In the lead up to and after birth, major changes occur to cardiomyocytes that result in regeneration no longer being possible; however, the timing of these events varies across species. Factors that regulate this cardiomyocyte transition include nutrient and oxygen availability, hormones and microRNAs. An emerging field of research is the use of biomarkers as a non-invasive detection method for cardiovascular disease.
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Bruton et al. (2003) studied this question.
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