SUMMARY The residual catecholamine content of the cat adrenal gland after the removal of much of the medulla contained a significantly higher percentage of adrenaline than that of the excised medulla. Fluorescent and phase microscopy showed that in these glands a layer of medullary tissue adjacent to the cortex still remained. The high concentration of adrenaline in chromaffin cells nearest to cortical tissue provides further evidence for the theory that the adrenal cortex acts to facilitate the formation of adrenaline from noradrenaline in the medulla.
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Rubin et al. (1968) studied this question.