Animal study demonstrates reduced toxicity and prolonged survival with liposomal actinomycin D in tumor-bearing mice, suggesting improved chemotherapy delivery.
Actinomycin D, when encapsulated within liposomes, is less toxic to mice than the nonencapsulated form. A single dose (0.75 mg/kg) or multiple doses (1 × 0.50, 4 × 0.25 mg/kg) significantly increased the mean survival time of mice inoculated with Ehrlich ascites tumor cells. Liposomes containing actinomycin D were found in tumor cells and cell degeneration and death were subsequently observed.
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Rahman et al. (1974) studied this question.
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