Key result
Intravenous lacosamide caused dose-dependent PR and QRS prolongation and ECG abnormalities in animals at exposures 1.5- to 2-fold above the maximum recommended human dose.
Lacosamide exhibits dose-dependent cardiac sodium channel inhibition leading to PR and QRS prolongation in preclinical models at exposures slightly above the maximum recommended human dose.
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May signal conduction risks at supratherapeutic exposures; leaves open relevance at approved human doses.
Delaunois et al. (2015) studied this question. Lacosamide was evaluated on hemodynamic and ECG parameters. Intravenous lacosamide caused dose-dependent PR and QRS prolongation and ECG abnormalities in animals at exposures 1.5- to 2-fold above the maximum recommended human dose.
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