Key result
New continuous numeric variables (Deltat, ShpD, and ACA) significantly correlated with a standard severity score for measuring pericardial adhesions (r=0.897, r=0.932, r=0.66; p<0.01).
Why the study?
Do new continuous numeric variables (Deltat, ShpD, ACA) correlate with standard severity scores for measuring postoperative pericardial adhesions in a swine model?
RCT (n=24)
Do new continuous numeric variables (Deltat, ShpD, ACA) correlate with standard severity scores for measuring postoperative pericardial adhesions in a swine model?
Effect estimate: r=0.897, r=0.932, r=0.66
p-value: p=<0.01
Time spent to dissect adhesions and the amount of sharp dissection are valid quantitative tools for measuring postoperative pericardial adhesions in experimental models.
Supports quantitative adhesion metrics in swine models; leaves open translation to human reoperations.
PURPOSE: To improve the measurement system, during a research for the prevention of adhesions, we explored the feasibility of introducing three continuous numeric variables to quantify the intensity of pericardial adhesions. METHODS: To validate these three new numeric variables - time spent to dissect the adhesions (Deltat), the amount of sharp dissection (ShpD) and the adhesion's collagen area (ACA) - as useful tools in measuring the severity of pericardial adhesions, data from a randomized study on adhesion prevention enrolling twenty-four swine, were analysed. A statistical Spearman's test and regressions models were applied to verify the correlation and the relationship between the results of a standard severity score (SS) and Deltat, between SS and ShpD used in adhesiolysis and, also, between SS and ACA. RESULTS: There was a statistically significant correlation between SS and Deltat, between SS and ShpD, as well as between SS and ACA, all measured by the Spearman's test (r=0.897, r=0.932, r=0.66; p<0.01, respectively). Through a non-linear regression, an exponential relation of SS with ShpD (R(2)=0.915) and SS with Deltat (R(2)= 0.917) was found. CONCLUSION: The time spent to dissect the adhesions (Deltat) and the amount of sharp dissection (ShpD) are new powerful measurement tools in evaluating outcomes of the methods used to prevent pericardial adhesions.
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Lopes et al. (2009) conducted an RCT in pericardial adhesions (n=24). Measurement using Deltat, ShpD, and ACA vs. Standard severity score (SS) was evaluated on Correlation between standard severity score (SS) and Deltat, ShpD, and ACA (r=0.897, r=0.932, r=0.66, p=<0.01). New continuous numeric variables (Deltat, ShpD, and ACA) significantly correlated with a standard severity score for measuring pericardial adhesions (r=0.897, r=0.932, r=0.66; p<0.01).