Commentary on “The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio”

Among pharmacokinetic concepts, clearance has been the most widely applied in clinical pharmacology and drug development. With so much written on the subject it might be thought that there is nothing more to say. So it is noteworthy that some basic aspects related to hepatic clearance, and specifically the most popular model, the well-stirred model, have been challenged by Benet et al. This commentary examines the challenge and provides our views.