Palladium-Catalyzed Cross-Methylation of Aryl Chlorides by Stabilized Dimethylaluminium and -Gallium Reagents

All articles of this category Two methods for palladium-catalyzed cross-methylation of aryl chlorides by intramolecularly stabilized dialkylaluminium and -gallium complexes 6-13 have been studied. In one method, in which either tetrakis(triphenylphosphine)palladium ( 1 ) or dichlorobis(triphenylphosphine)palladium ( 2 ) is used as the catalyst at 80-90 °C, the activation of the chlorine atom is affected by introduction of strong electron-withdrawing groups into the aromatic moiety. The second method is based on the application of either [1,3-bis(diisopropylphosphino)propane)]palladium ( 4 ) or homologous electron-rich palladium complexes as catalysts. Although 4 promotes smooth cross-alkylation of aryl chlorides it fails to activate simple aryl bromides. aryl chlorides - aluminium complexes - gallium complexes - cross-coupling - palladium(0) catalysis