Key result
Destruction of the canine right ventricular Purkinje-net system using dilute Lugol's solution produced an intraventricular conduction defect 20 to 30 msec longer than right bundle-branch block.
Population
Canine model
Comparison
Introduction of dilute Lugol's solution into the… vs Right bundle-branch block (reference standard)
Design
Preclinical
Authors
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Indicates Purkinje contribution to QRS duration beyond RBBB in canines; leaves open relevance to human conduction disorders.
Effect estimate: 20 to 30 msec greater in duration than right bundle-branch block
Destruction of the right ventricular Purkinje network in a canine model produces a distinct intraventricular conduction defect wider than typical right bundle-branch block.
Wennemark et al. (1962) studied Intraventricular conduction defect. Introduction of dilute Lugol's solution into the right ventricular cavity vs. Right bundle-branch block was evaluated on Intraventricular conduction defect duration and activation pattern (20 to 30 msec greater in duration than right bundle-branch block). Destruction of the canine right ventricular Purkinje-net system using dilute Lugol's solution produced an intraventricular conduction defect 20 to 30 msec longer than right bundle-branch block.
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