Effect of Renal Disease on the Schilling Test

THE diagnosis of pernicious anemia has become increasingly difficult with the widespread use of "panhematinics" containing folic acid. These preparations may correct the hematologic picture and yet allow the progression of combined-system disease.1 Conley et al.2 showed that large doses of parenterally injected B12 are almost quantitatively excreted in the urine during the first twenty-four hours after injection. Schilling3 utilized this observation to simplify the test of fecal excretion of cobalt60-labeled vitamin B12 introduced by Heinle and his associates.4 The Schilling test, which is simple, practical and useful, has now been widely used and reported5 6 7 8 9 in various . . .