Key result
Genome analysis of a porcine group C rotavirus strain from China revealed a natural recombination event in the VP2 gene and a new branch A10 based on nsp1.
Why the study?
Due to a lack of disease awareness and molecular diagnostic means, research on porcine group C rotavirus infection in China has not been well-studied.
The study identifies a potentially novel gene recombination event in the VP2 gene of porcine group C rotavirus in China, providing new insights into rotavirus evolution.
Supports expanded rotavirus surveillance in swine; leaves open zoonotic or vaccine implications pending further study.
Swine enteric disease is the predominant cause of morbidity and mortality, and viral species involved in swine enteric disease include rotaviruses and coronaviruses, among others. Awareness of the circulating porcine rotavirus group C (PoRVC) in pig herds is critical to evaluate the potential impact of infection. At present, due to the lack of disease awareness and molecular diagnostic means, the research on RVC infection in China is not well-studied. In this study, diarrhea samples collected from pig farms were detected positive for RVC by PCR, and the full-length RVC was not previously reported for Chinese pig farms. This rotavirus strain was designated as RVC/Pig/CHN/JS02/2018/G6P6. A natural recombination event was observed with breakpoints at nucleotides (nt) 2509 to 2748 of the VP2 gene. Phylogenetic analysis based on nsp1 revealed that a new branch A10 formed. Collectively, our data suggest a potentially novel gene recombination event of RVC in the VP2 gene. These findings provide a new insight into the evolution of the rotavirus.
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Jiao et al. (2022) studied Porcine rotavirus group C infection. Genome analysis of RVC/Pig/CHN/JS02/2018/G6P6 was evaluated on Genome sequence and phylogenetic analysis. Genome analysis of a porcine group C rotavirus strain from China revealed a natural recombination event in the VP2 gene and a new branch A10 based on nsp1.
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