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Novel N ‐aryltriazole nucleosides were synthesized via a Cu‐mediated CN cross‐coupling reaction, using 3‐aminotriazole acyclonucleosides and various boronic acid reagents. Interestingly, N ‐arylation proceeded much more rapidly on the amide group than on the amine group, leading to selective N ‐arylation of the amide functionality on nucleosides containing both groups on the triazole nucleobase.
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Li et al. (2009) studied this question.
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