Metabolites of Microorganisms. Synthesis of 3‐Isobutyl‐4,5‐dimethylisoindolin‐1‐one, a Degradation Product of Aspochalasin D 3‐Isobutyl‐4,5‐dimethylisoindolin‐1‐one (1) and 3‐isobutyl‐6, 7‐dimethyl‐isoindolin‐1‐one (6) were synthesized in a non‐regioselective way. The structures could be assigned unequivocally by spectroscopic means. Compound 1 was identical with a degradation product of Aspochalasin D.
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Kupfer et al. (1979) studied this question.
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