Total Synthesis of Antioxidant Alkaloid Carazostatin via Electrocyclic Ring Closure of 3-Butadienyl-2-methoxyindole

Total synthesis of the naturally occurring antioxidant carazostatin was accomplished by an efficient method, Wittig reaction of 2-methoxyindol-3-one followed by electrocyclic reaction of 3-(1,3butadienyl)indole.Antioxidants are served as possible protective agents against a variety of diseases induced by oxygen-derived free radicals, like myocardial and cerebral ischemia, arteriosclerosis, inflammation, rheumatism, senility, autoimmune diseases, and cancer. 1 Recently, as a novel