⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

January 1, 1986The Journal of AntibioticsOpen Access

PD 116,152, a novel phenazine antitumor antibiotic discovery, fermentation, culture characterization and biological activity.

Josefino B. Tunac Stephen W. Mamber Danielle Graham William E. Dobson

View Full Paper

Ask AI

Bookmark

Share

Abstract

A novel phenazine antitumor antibiotic is described, produced by Streptomyces lomondensis subsp. galanosa NRRL 15738. The antibiotic is selectively active versus the bacterium Streptococcus pneumoniae (MIC less than 0.46 microgram/ml); the antitumor activity versus murine P388 leukemia is T/C 149.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Tunac et al. (1986) studied this question.

synapsesocial.com/papers/6a9cc91940107bcd3e417e04 https://doi.org/10.7164/antibiotics.39.192

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 related papers. Consider them for comparative context:

1Isolation and characterization of 5-O-desmethyl kinanthraquinone B generated through O-methyltransferase gene disruptionThe Journal of Antibiotics · Mon,
2In vitro activity and comparative efficacy of novel nitrofuran-containing ciprofloxacin analogs against bacterial pathogens including ciprofloxacin-resistant Staphylococcus aureusThe Journal of Antibiotics · Fri,
3P450 cyptide synthase KwwB catalyzes non-native cross-link at Tyr-C3–Trp-N1 and tolerates leader peptide mutationsThe Journal of Antibiotics · Mon,
4Amino acid mapping–guided scaffold selection and hit identification of histidine kinase inhibitors from a virtual library of over 12 million compoundsThe Journal of Antibiotics · Wed,
5Biosynthesis and enzymology of azaindane natural productsThe Journal of Antibiotics · Mon,

More from The Journal of Antibiotics

Salt-induced 7-deoxypactamycin and oligomycin production in Streptomyces sp. strain TUA-HK1GM isolated from kusaya gravyTue,
Inhibition of the SOS response by olivetol improves the efficacy of DNA-damaging antibiotics in Escherichia coliThu,
Discovery of actinomycin derivatives with improved selectivity against malaria parasites from a Streptomyces culture libraryThu,
Comparative activity of sulbactam and sulbactam/durlobactam against carbapenem-resistant A. baumannii isolates producing OXA-23 or OXA-23 plus PER-1 enzymesFri,
Four new hydroxyl fatty acids, gambaoic acids A-C and gambaoic B methyl ester, from Shrimp Jeotgal-derived Bacillus sp. SNB-066Fri,