Persistent Nephrogenic Diabetes Insipidus after Lithium Carbonate

Letters1 April 1977Persistent Nephrogenic Diabetes Insipidus after Lithium CarbonateNORMAN M. SIMON, M.D., F.A.C.P., ELAYNE GARBER, M.D., ALEX J. ARIEFF, M.D.NORMAN M. SIMON, M.D., F.A.C.P., ELAYNE GARBER, M.D., ALEX J. ARIEFF, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-4-446 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptLithium salts are effective in the management of manicdepressive psychosis. The margin of safety with their use is low so that significant side-effects may occur even when blood levels are in the therapeutic range. Among these complications are nephrogenic diabetes insipidus, which to date has been described as transient and reversible within weeks of cessation of treatment (1). The case reported herein is noteworthy in that diabetes insipidus persisted 20 months after the last chronic exposure to lithium carbonate.A 54-year-old man with a history of manic-depressive psychosis since age 19 had been treated with electroshock, insulin shock, tranquilizers, and...References1. BALDESSARINILIPINSKI RJ: Lithium salts: 1970-1975. Ann Intern Med 83:527-533, 1975 LinkGoogle Scholar2. MILLERDALAKOSMOSES MTA: Recognition of partial defects in antidiuretic hormone secretion. Ann Intern Med 73:721-729, 1970 LinkGoogle Scholar3. FORRESTCOHENTORRETTI JAJ: On the mechanism of lithium-induced diabetes insipidus in man and the rat. J Clin Invest 53:1115-1123, 1974 CrossrefMedlineGoogle Scholar4. SINGERROTENBERG ID: Mechanisms of lithium action. N Engl J Med 289:254-260, 1973 CrossrefMedlineGoogle Scholar5. EVANOLLERICH AD: The effect of lithium carbonate on the structure of the rat kidney. Am J Anat 134:97-106, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Section of Nephrology-Hypertension Departments of Medicine and Neurology Northwestern University Medical School Chicago, IL 60611 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPartial nephrogenic diabetes insipidus associated with lithium therapyNephrotoxicity of Lithium and Drugs of AbuseLithium-Induced Nephrogenic Diabetes Insipidus After Gastric BandingNephrotoxicity of Lithium and Drugs of AbuseLithium-associated kidney effectsCauses of reversible nephrogenic diabetes insipidus: A systematic reviewLithium-induced renal effectsNephrogenic Diabetes Insipidus Persisting 57 Months after Cessation of Lithium Carbonate Therapy: Report of a Case and Review of the LiteratureLithium and the kidneyPersistent Nephrogenic Diabetes Insipidus following Lithium TherapyLithium-induced diabetes insipidus in a surgical patient: Report of a case and review of the literatureDrug-Induced Renal DisordersBipolar Affective DisordersPersistent nephrogenic diabetes insipidus, tubular proteinuria, aminoaciduria, and parathyroid hormone resistance following longterm lithium administration.The use of lithium in the medically ill9 Polyuric states in manPrevalence, Pathogenesis, and Treatment of Renal Dysfunction Associated With Chronic Lithium TherapyHypernatraemia due to a reset osmostat for vasopressin release and thirst, complicated by nephrogenic diabetes insipidus.Self-poisoning and Therapeutic Intoxication with LithiumInterstitial nephropathies and pyelonephritis in the agedInvestigating renal function during lithium treatmentRenal function in 153 manic-depressive patients treated with lithium for more than five yearsAmelioration of Polyuria by Amiloride in Patients Receiving Long-Term Lithium TherapyCase 17-1981Lithium and the kidneyLithiumLong-Term Lithium Treatment and the KidneyPharmacology and Toxicology of LithiumRenal Side-Effects of LithiumElectrolyte and Water Balance Side-Effects of LithiumU.K. National Cancer Trials— Unstarted BusinessLITHIUM NEPHROPATHYLithium and Diabetes InsipidusTREVOR R.P. PRICE, M.D., PAUL J. BEISSWENGER, M.D.Lithium 1 April 1977Volume 86, Issue 4Page: 446-447KeywordsBipolar disorderBloodCarbonatesElectroconvulsive therapyInsulinSafetySaltsShock Issue Published: 1 April 1977 PDF DownloadLoading ...