Key result
Intraplaque microvascular flow scoring by AngioPLUS was positively correlated with plaque characteristics and consistent with contrast-enhanced ultrasound scores in carotid atherosclerosis.
Why the study?
CEUS detects intraplaque neovascularization, but its invasiveness and complexity limit clinical application, prompting investigation of the AngioPLUS technique.
Does the AngioPLUS (AP) technique accurately assess intraplaque neovascularization compared to contrast-enhanced ultrasound in patients with atheromatous carotid artery plaque?
Observational
Does the AngioPLUS (AP) technique accurately assess intraplaque neovascularization compared to contrast-enhanced ultrasound in patients with atheromatous carotid artery plaque?
The AngioPLUS technique offers a promising, non-invasive alternative to contrast-enhanced ultrasound for assessing intraplaque neovascularization and plaque status in carotid atherosclerosis.
AP may support non-contrast carotid plaque assessment; leaves open whether it can guide clinical decisions without prospective validation.
BACKGROUND: Contrast-enhanced ultrasound (CEUS) is a routine technique for detecting intraplaque neovascularization (IPN). However, the invasiveness and complexity of CEUS severely limit its clinical application. This article aims to investigate the application value of AngioPLUS (AP) technique in assessing IPN formation in patients with atheromatous (AS) carotid artery plaque. METHODS: Patients diagnosed with carotid artery atherosclerosis combined plaque formation were recruited and their demographic characteristics including serum fasting blood glucose (FBG), triglyceride (TG), and low-density lipoprotein (LDL) were collected. AP was used to scoring intraplaque microvascular flow (IMVF), measuring the thickness and length of the plaque and determining the number of IPN of the plaque. RESULTS: IMVF score evaluated by AP was positively correlated with plaque length, thickness, IPN number, serum TG, LDL and FBG levels in patients with carotid atherosclerosis with plaque. The evaluation results of CEUS score and IMVF classification detected by AP of plaques were consistent in patients with carotid atherosclerosis. CONCLUSION: IMVF scoring by AP is a promising approach to assess IPN and plaque status in patients with atheromatous carotid artery plaque.
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Chen et al. (2022) conducted an observational in Atheromatous carotid artery plaque. AngioPLUS (AP) technique vs. Contrast-enhanced ultrasound (CEUS) was evaluated on Intraplaque microvascular flow (IMVF) score and correlation with plaque characteristics. Intraplaque microvascular flow scoring by AngioPLUS was positively correlated with plaque characteristics and consistent with contrast-enhanced ultrasound scores in carotid atherosclerosis.
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