Tissue Calcification and Renal Failure Produced by Massive Dose Vitamin D Therapy of Arthritis

Article1 July 1945TISSUE CALCIFICATION AND RENAL FAILURE PRODUCED BY MASSIVE DOSE VITAMIN D THERAPY OF ARTHRITIST. S. DANOWSKI, M.D., A. W. WINKLER, F.A.C.P., J. P. PETERS, M.D.T. S. DANOWSKI, M.D.Search for more papers by this author, A. W. WINKLER, F.A.C.P.Search for more papers by this author, J. P. PETERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-1-22 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMassive doses of vitamin D have been used in the treatment of arthritis during the past decade.1, 2 Symptoms and physical disabilities of some patients have apparently improved on this régime. The clinical reports have usually implied that the toxic effects of these large doses are insignificant.3, 4, 5, 6, 7 In this report two cases of renal damage secondary to prolonged therapy with vitamin D are described. In one of these extensive calcification of soft tissues was readily demonstrable.CASE REPORTSCase 1(E. S.) This English housewife was first admitted to New Haven Hospital in 1932 at the...Bibliography1. RAPPAPORTREED BZCI: Viosterol of high potency in seasonal hay fever and related conditions, Jr. Am. Med. Assoc., 1933, ci, 105-109. CrossrefGoogle Scholar2. DREYERREED ICI: The treatment of arthritis with massive doses of vitamin D, Arch. Phys. Therap., 1935, xvi, 537-540. Google Scholar3. FARLEYSPIELINGKRAINES RTHFSH: Five year study of arthritis patients. Laboratory and clinical observations, Indust. Med., 1941, x, 341-352. Google Scholar4. SNYDERSQUIRES RGWH: A preliminary report on activated ergosterol. Form of high dosage vitamin D in treatment of chronic arthritis, New York State Jr. Med., 1940, xl, 708-719. Google Scholar5. SNYDERSQUIRESFORSTERTRAEGERWAGNER RGWHJWCHLC: The treatment of two hundred cases of chronic arthritis with electrically activated vaporized sterol, Indust. 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Chemistry, physiology, pharmacology, experimental and clinical investigation, 1939, University of Chicago Press, Chicago, 262. Google Scholar19. ROBBINS CL: The effect of dinitrophenol on calcium and phosphorus metabolism, Jr. Nutr., 1935, x, 187-191. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New Haven, Connecticut*Received for publication February 23, 1945.From the Department of Internal Medicine, Yale University School of Medicine. 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H. PETERS, M.D., R. H. HORN, M.D., L. GREENMAN, M.D.Conjunctival and Corneal Calcification in HypercalcemiaHypercalcemia without Hypercalcuria or Hypophosphatemia, Calcinosis and Renal InsufficiencyVitamin D Intoxication in a Case of Parathyropriral TetanyVITAMIN D THERAPY IN CUTANEOUS TUBERCULOSIS.*TREATMENT OF LUPUS VULGARIS WITH CALCIFEROL 1 July 1945Volume 23, Issue 1Page: 22-29KeywordsArthritisDiagnostic radiologyDisabilitiesHospital medicineRenal failureSoft tissuesVitamin D ePublished: 1 December 2008 Issue Published: 1 July 1945 PDF downloadLoading ...