Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling
Key result
Myosin-binding protein C corrects nonuniformity in calcium activation by sensitizing the contractile apparatus to calcium, counterbalancing the calcium gradient across the sarcomere.
Population
Cardiac sarcomeres / contractile apparatus
Design
Preclinical
Authors
Discussion
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Member takes
Implication
MyBP-C ensures uniform sarcomere activation in animal models; leaves open whether targeting it could modulate human contractility.
Structured PICO
P
Population
Cardiac sarcomeres / contractile apparatus
E
Exposure
Myosin-binding protein C (MyBP-C)
O
Outcome
Correction of nonuniformity in calcium activation during cardiac excitation-contraction couplingsurrogate
The presence and correct localization of MyBP-C within the sarcomere is critically important for normal cardiac function by ensuring uniform activation of contraction.
Cite This Study
Previs et al. (2015) studied Cardiac function. Myosin-binding protein C (MyBP-C) was evaluated on Correction of nonuniformity in calcium activation. Myosin-binding protein C corrects nonuniformity in calcium activation by sensitizing the contractile apparatus to calcium, counterbalancing the calcium gradient across the sarcomere.