In recent years, the molecular etiology of parkinsonism has yielded to genetic analysis.1 Mutations in the gene leucine-rich repeat kinase 2 ( LRRK2 ) have the highest genotypic and population attributable risk. Disparate penetrance estimates have been reported using a variety of statistical analyses, ethnic populations, and sample sizes.2 We compared the age-associated cumulative incidence (penetrance) of LRRK2 p.G2019S patients from Tunisia and Norway. Acknowledgment: The authors thank the individuals who participated in this study; Emil Gustavsson, Ilaria Guella, and Carles Vilarino-Guell for review comments; and Rachel Gibson, Lefkos Middleton, and the GlaxoSmithKline program team for prior collaborative efforts in Tunisia.
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Hentati et al. (2014) studied this question.
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