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IL-27 has been linked with immune regulation during infection, but this is the first report of a combined influence of IL-27 on complete host response during systemic infection with metabolic fitness in a neonate. Novel findings demonstrate improved glucose homeostasis and insulin response supported by a reduced expression of genes involved in gluconeogenesis in the absence of IL-27 signaling. An increased expression of genes integral to cholesterol biosynthesis further supports a protective response during sepsis.
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Povroznik et al. (2025) studied this question.
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