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The focus of this contribution is on the understanding of solubility that is a prerequisite to any meaningful measurement, reporting, and interpretation of solubility data. A brief reprise of the thermodynamics of solubility is followed by a summary of ‘excess solvent’ and ‘excess solid’ methods of measurement in common usage. Case studies illustrate how temperature, polymorph, water, and impurities can change the measured solubility by factors of 2 or more. The interplay between these factors and the method of measurement is explored, drawing on the differing academic, industrial, and geographical perspectives of the authors.
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Black et al. (2013) studied this question.
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