Key result
18F-FDG PET/CT and 123I-MIBG SPECT/CT aided in the diagnostic workup of a malignant peripheral nerve sheath tumor of the pericardium in a patient with neurofibromatosis type 1.
Case Report (n=1)
18F-FDG PET/CT and 123I-MIBG SPECT/CT can be useful in the diagnostic workup of pericardial masses in patients with neurofibromatosis type 1.
A 25-y-old woman with known neurofibromatosis type 1 and a large anterior mediastinal mass was investigated. 18F-FDG PET/CT revealed a radiotracer-avid anterior mediastinal mass having an SUVmax of 4.3 and demonstrating a hypoactive center. The 123I-metaiodobenzylguanidine SPECT/CT study performed subsequently did not demonstrate any uptake, thereby excluding, for the most part, the diagnosis of paraganglioma or neuroblastoma. At final pathology, a malignant peripheral nerve sheath tumor of the pericardium with areas of chondrosarcomatous and angiosarcomatous differentiation was diagnosed.
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Charest et al. (2017) conducted a case report in Malignant peripheral nerve sheath tumor of the pericardium in neurofibromatosis type 1 (n=1). 18F-FDG PET/CT and 123I-MIBG SPECT/CT was evaluated on Diagnosis of the mediastinal mass. 18F-FDG PET/CT and 123I-MIBG SPECT/CT aided in the diagnostic workup of a malignant peripheral nerve sheath tumor of the pericardium in a patient with neurofibromatosis type 1.
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