Three new withanolide compounds named baimantuoluoline A (1), B (2), and C (3) and the two known withanolides withafastuosin E (4) and withametelin C (5) were isolated from the fraction exhibiting activity for psoriasis in the flower of Datura metel L. The three new structures were determined as (5α,6α,7α,12β,15β,22R)‐6,7‐epoxy‐5,12,15‐trihydroxy‐1‐oxowitha‐2,24‐dienolide (1), (5α,6β,15β,22R)‐ 5,6,15,21‐tetrahydroxy‐1‐oxowith‐24‐enolide (2), and (5α,6β,12β,22R)‐5,6,12,21‐tetrahydroxy‐27‐methoxy‐1‐oxowitha‐2,24‐dienolide (3) on the basis of extensive spectroscopic data (HR‐ESI‐MS, 1H‐ and 13C‐NMR, 1H,1H‐COSY, HSQC, HMBC, and NOESY) (withanolide=22‐hydroxyergostan‐26‐oic acid δ‐lactone).
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Yang et al. (2007) studied this question.
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