Key result
Age-specific reference intervals for the prostate health index (phi) were established in 732 healthy men, ranging from 9.77-48.44 in men <40 years to 8.16-40.76 in men ≥60 years.
Why the study?
Biomarkers p2PSA, %p2PSA, and phi aid prostate cancer diagnosis and grading, but few studies have evaluated these parameters in a healthy population.
Cross-Sectional (n=732)
This study establishes age-specific reference intervals for novel prostate cancer biomarkers (p2PSA, %p2PSA, and phi) in healthy men to aid in clinical decision-making.
May support age-specific phi references for prostate cancer evaluation; leaves open prospective validation before clinical adoption.
Background: Prostate cancer (PCa) is the second most common cancer among men worldwide. Recent research has identified [−2]proPSA (p2PSA), %p2PSA and prostate health index ( phi ) as new biomarkers for the early diagnosis and grading of PCa. However, few studies have used these parameters in a healthy population. In this study, we aimed to establish reference intervals (RIs) for p2PSA, %p2PSA and phi in healthy men based on age stratification. Methods: Between April 2016 and March 2018, healthy subjects were recruited. Healthy men were then stratified into four age groups: <40 years, 40–49 years, 50–59 years and ≥60 years. Total PSA (tPSA), free PSA (fPSA), %fPSA, p2PSA, %p2PSA and phi were measured and RIs were established for p2PSA, %p2PSA and phi . Results: In total, 732 healthy men were used for analysis. The RIs of phi were 9.77–48.44 for <40 years of age, 9.85–65.28 for 40–49 years of age, 9.98–39.72 for 50–59 years of age and 8.16–40.76 for ≥60 years of age. The reference values at the age of 40–49 years were generally higher than those at ≥60 years of age. Conclusions: Age-specific RIs for p2PSA, %p2PSA and phi were established in this study. This first set of established RIs will be invaluable for physicians to make precise medical decisions and carry out appropriate medical interventions.
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Wu et al. (2019) conducted a cross-sectional in Healthy (n=732). Prostate biomarkers (p2PSA, %p2PSA, phi) was evaluated on Reference intervals for p2PSA, %p2PSA and phi. Age-specific reference intervals for the prostate health index (phi) were established in 732 healthy men, ranging from 9.77-48.44 in men <40 years to 8.16-40.76 in men ≥60 years.
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