What question did this study set out to answer?

To determine whether stress from social defeat and repeated attacks by conspecifics activates endogenous opioid-mediated pain suppression in mice.

March 19, 1982Science

Opioid-Like Analgesia in Defeated Mice

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Authors

KMKlaus A. MiczekTufts University MTMichael L. Thompson LSLouis ShusterDartmouth College

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Implication

Laboratory study demonstrates opioid-dependent analgesia in defeated mice, suggesting endogenous pain-relief pathways activate during biologically significant stress.

Key Points

To determine whether stress from social defeat and repeated attacks by conspecifics activates endogenous opioid-mediated pain suppression in mice.
Subjected mice to repeated physical attacks (social defeat) by other mice.
Assessed pain sensitivity by measuring nociceptive responses to radiant heat applied to the tail.
Tested the involvement of opioid mechanisms using centrally acting opiate antagonists, morphine-tolerant mice, and opioid-deficient CXBK strain mice.
Defeated mice showed marked analgesia, demonstrating significantly reduced nociceptive sensitivity to radiant heat.
The analgesic effect was abolished by centrally acting opiate antagonists and was entirely absent in morphine-tolerant mice.
Mice of the CXBK strain displayed only moderate analgesia following defeat, confirming an endogenous opioid-dependent mechanism.

Cite This Study

Miczek et al. (1982) studied this question.

synapsesocial.com/papers/6a9cd7bd348d48b51ae27607 https://doi.org/10.1126/science.7199758

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Implication

Laboratory study demonstrates opioid-dependent analgesia in defeated mice, suggesting endogenous pain-relief pathways activate during biologically significant stress.

Opioid-Like Analgesia in Defeated Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Opioid-Like Analgesia in Defeated Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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