Summary: Genetic recombination occurs with a rather high frequency (up to 10-3) in mixed cultures of auxotrophic and streptomycin-resistant mutant derivatives of Thermo-actinomyces vulgaris strain t9 growing on agar medium. It is shown that transformation by DNA is responsible for this recombination. Certain other newly isolated strains resemble t9 in being competent for transformation and are interfertile with each other and with t9. Some other strains are incompetent but can act as donors to the first set of strains. A fully synthetic minimal medium and conditions for efficient mutagenesis have been defined.
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Hopwood et al. (1972) studied this question.
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