A simple assembly of commercially available materials, namely, zinc triflate (Zn(OTf)2), a tertiary amine base (iPr2EtN), and reusable (+)-N-methylephedrine, effectively activates the Henry reaction between aldehydes and nitromethane (see scheme). The catalytic system can be used in substoichiometric quantities and leads to good yields and enantioselectivities.
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Palomo et al. (2005) studied this question.
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