Differences in Protein Profiles in Schizophrenia Prefrontal Cortex Compared to Other Major Brain Disorders

This is the authors' abstract. We don't add key points for this paper.

We are approaching the challenge of elucidating novel mechanisms in neuropsychiatric disease by using high-throughput global profiling methods, with an emphasis on pathway and functional changes. Previous studies from our laboratory have suggested a role for abnormal brain metabolism in the pathophysiology of schizophrenia. Applying these methods across disorders allows us to pinpoint unique molecular disease signatures as distinct from general indicators of compromised brain function. 2D-DIGE was used to investigate the protein profile of tissue from dorsolateral prefrontal cortex (gray and white matter) from patients with bipolar disorder, Down's syndrome, Alzheimer's disease, and control subjects. Differentially expressed proteins were sequence identified and organised according to functional category and compared to our previous findings from schizophrenia samples. Down's syndrome and Alzheimer's samples gave highly similar results to each other, with all differentially expressed proteins being upregu...