Key result
A review of 20 murine mutants with inherited neuromuscular diseases was conducted to provide information on animal models for human neuromuscular diseases.
This review highlights 20 murine mutants as valuable animal models for studying human inherited neuromuscular diseases.
May inform preclinical neuromuscular research; leaves open translation to human therapies.
There are several neuromuscular disorders affecting the human being. Most of these are poorly understood and lack and effective treatment. Due to the limitation of experimental manipulation in "anima nobili", inherited neuromuscular diseases in laboratory animals constitute a valuable source of scientific information. Amongst several animal species affected by neuromuscular disorders the house mouse is of particular interest because of its small size, short pregnancy and low costs of maintanence. In the present review 20 murine mutants with diseases affecting peripheral nerves, skeletal muscles and motor end-plates are tabulated. Genetic, clinical and pathological aspects are discussed aiming to provide information about these mutants which might be of great interest as animal models for human neuromuscular diseases.
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Luíz Fernando Bleggi Torres (1988) conducted a review in Inherited neuromuscular diseases (n=20). Murine mutants (animal models) was evaluated. A review of 20 murine mutants with inherited neuromuscular diseases was conducted to provide information on animal models for human neuromuscular diseases.
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