EEG Changes and Serum Cortisol Levels in Cushing's Syndrome

Thirty-three patients with Cushing's syndrome had baseline serum cortisol levels and EEG's prior to medical treatment. The EEG's were often normal or showed minor abnormalities consisting of mild slowing and disorganization of background activity, excessive fast activity, and minor paroxysmal changes with sharp waves and some small spike-waves. Of 30 not having intracranial tumors there was a general trend toward worsening of the EEG with increased serum cortisol levels.