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February 1, 2004Antiviral TherapyOpen Access

Safety and Efficacy of a Nrti-Sparing Haart Regimen of Efavirenz and Lopinavir/Ritonavir in HIV-1-Infected Children

Pieter LA Fraaij Jennifer Neubert Alina S Bergshoeff Annemarie M. C. van Rossum Nico G. Hartwig Horst Schroten Klaus Korn David M. Burger Ronald de Groot Tim Niehues

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Abstract

We studied a nucleoside reverse transcriptase inhibitor (NRTI)-sparing regimen for the treatment of children infected with NRTI-resistant HIV-1. The combination of lopinavir/ritonavir and efavirenz suppressed HIV-1 levels for a prolonged period and resulted in a significant increase in CD4+ T cell numbers despite an extensive prior treatment with NRTI (>4 years). Observed side effects were transient with the exception of dyslipidaemia.

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Fraaij et al. (2004) studied this question.

synapsesocial.com/papers/6a9cece18f152f04b0b7a91d https://doi.org/10.1177/135965350400900211

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