Key result
Retinal microvascular abnormalities and cerebral white matter changes were significantly associated with a higher multidimensional frailty index in older adults (P<0.001).
Cross-Sectional (n=87)
No
Effect estimate: B = -1.22
p-value: p=<.001
In older Korean adults, frailty is significantly associated with retinal microvascular changes and cerebral white matter abnormalities, suggesting a potential role of microvascular aging in the pathophysiology of frailty.
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Supports microvascular contributions to frailty; hypothesis-generating and should not change practice without longitudinal data.
Jung et al. (2014) conducted a cross-sectional in Frailty (n=87). Retinal microvascular and cerebral white matter changes vs. Absence or lower severity of microvascular changes was evaluated on Multidimensional frailty index (B = -1.22, p=<.001). Retinal microvascular abnormalities and cerebral white matter changes were significantly associated with a higher multidimensional frailty index in older adults (P<0.001).
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