Next‐Generation Pluronic Micelles for Advanced Drug Delivery Application

Pluronics are synthetic, amphiphilic triblock copolymers consisting of hydrophilic polyethylene oxide (PEO) segments and hydrophobic polypropylene oxide (PPO) segments arranged in a PEO–PPO–PEO configuration. Owing to their amphiphilic nature, these polymers can spontaneously organize or associate with other components to generate micellar nanocarriers, supporting diverse applications across pharmaceutical and related fields. Their favorable properties, including biocompatibility, low toxicity, biodegradability, and efficient micelle formation, make them particularly attractive for drug delivery systems. Furthermore, chemical or biological modification of Pluronics can introduce stimuli‐responsive characteristics, facilitating controlled, sustained, and site‐specific drug release. This review summarizes the structural attributes, classifications, and synthesis approaches of Pluronics, and discusses the use of Pluronic‐based micelles for drug and gene delivery across multiple administration routes, including oral, topical, ocular, brain, pulmonary, and tumor‐targeted systems, with emphasis on both in vitro and in vivo evaluations.