Silicon chemistry has been demonstrated to be a novel source of chemical diversity in odorant design. The carbon/silicon switch strategy, i.e., sila-replacement in known odorants, is one of the methods currently used for the development of silicon-based odorants. Examples resulting from this strategy are sila-coranol, sila-dimetol, sila-linalool, sila-muguetalcohol, sila-majantol, sila-hydratropyl acetate, sila-bourgeonal, sila-lilial, disila-versalide, and disila-okoumal.
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Tacke et al. (2008) studied this question.
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