The Chemistry of Vitamin K

Article1 October 1941THE CHEMISTRY OF VITAMIN KLOUIS F. FIESER, PH.D.LOUIS F. FIESER, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-4-648 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the following paper such aspects of the chemistry of vitamin K are surveyed as have a direct bearing on the present and future status of the use of this vitamin factor in practical therapy. The vitamin has proved very efficacious in the limited but important field of the treatment of hypoprothrombinemia associated chiefly with obstructions of the biliary tract and with the bleeding tendency of the newborn. The possibility of the uncovering of other clinical applications should not be overlooked.Following Dam's discovery of the existence of a dietary antihemorrhagic factor in 1929,1a brief period of a few...Bibliography1. 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FRANKHURWITZSELIGMAN HAAAM: The treatment of hypoprothrombinemia with synthetic vitamin K1, report of two cases, New England Jr. Med., 1939, ccxxi, 975-977. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cambridge, Massachusetts*Read at the Boston meeting of the American College of Physicians, April 23, 1941. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byComparative Biochemistry of the Phenolase ComplexBiosynthesis of a Thiouracil Pheomelanin in Embryonic Pigment Cells Exposed to ThiouracilErythrocyte membrane interactions with menadione and the mechanism of menadione-induced hemolysisVitamin K and Biosynthesis of Protein and ProthrombinTurnover time prothrombin and of prothrombin messenger RNA and evidence for a ribosomal site of action of vitamin K in prothrombin synthesisMelanoproteins I. reactions between enzyme-generated quinones and amino acidsGlobin-haemochromogen formation caused by quinonesSTUDIES ON THE REACTION OF MENADIONE WITH BLOOD AND DENATURED PROTEINSLiver Respiration, Succinoxidase and DPN-Cytochrome C Reductase Activity in Vitamin K-Deficiency and after Treatment with Long-acting Anticoagulants.The Treatment of Hemorrhagic DiseasesThe Clinical Administration of Vitamin KCLINICAL ASPECTS OF HYPOPROTHROMBINEMIAVitamin KREACTIONS OF 2-METHYL-1,4-NAPHTHOQUINONE WITH WHOLE BLOOD AND PLASMA STUDIED BY MEANS OF A RAPID COLORIMETRIC METHOD 1 October 1941Volume 15, Issue 4Page: 648-658KeywordsBiliary systemForecastingHemorrhageHemostaticsVitamin K Issue Published: 1 October 1941 PDF downloadLoading ...