Cobalt 'n' cross-coupling! A facile and practical strategy catalyzed by CoCl(2)6 H(2)O has been developed for the N-arylation of nitrogen nucleophiles with substituted aryl halides in water. The protocol is very simple and requires only mild conditions. A variety of nitrogen nucleophiles, including pyrazole, indole, and 7-azaindole, undergo catalysis to afford N-arylated products in moderate to good yields (up to 86 %; see scheme).
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Teo et al. (2009) studied this question.
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