Key result
Treatment with grape seed and skin extract counteracted almost all adverse effects of doxorubicin-induced renal toxicity and oxidative stress in healthy rats.
Why the study?
Does grape seed and skin extract protect against doxorubicin-induced renal toxicity in healthy rats?
Does grape seed and skin extract protect against doxorubicin-induced renal toxicity in healthy rats?
Answers are grounded in this paper and cite their sources.
Grape seed and skin extract demonstrates antioxidant properties that protect against doxorubicin-induced renal toxicity in a rat model.
The study investigated the protective effect of grape seed and skin extract (GSSE) against doxorubicin-induced renal toxicity in healthy rats. Animals were treated with GSSE or not (control), for 8 days, administered with doxorubicin (20mg/kg) in the 4th day, and renal function as well as oxidative stress parameters were evaluated. Data showed that doxorubicin induced renal toxicity by affecting renal architecture and plasma creatinine. Doxorubicin also induced an oxidative stress characterized by an increase in malondialdehyde (MDA), calcium and H(2)O(2) and a decrease in catalase (CAT) and superoxide dismutase (SOD). Unexpectedly doxorubicin increased peroxidase (POD) and decreased carbonyl protein and plasma urea. Treatment with GSSE counteracted almost all adverse effects induced by doxorubicin. Data suggest that doxorubicin induced an oxidative stress into rat kidney and GSSE exerted antioxidant properties, which seem to be mediated by the modulation of intracellular calcium.
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Meherzia Mokni (2016) studied Doxorubicin-induced renal toxicity. Grape seed and skin extract (GSSE) vs. Control (no GSSE) was evaluated on Renal function and oxidative stress parameters. Treatment with grape seed and skin extract counteracted almost all adverse effects of doxorubicin-induced renal toxicity and oxidative stress in healthy rats.
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