Occurrence of Cryptococcus Neoformans in the Environment of Three Geographically Associated Cases of Cryptococcal Meningitis

ABOUT 500 cases of human infection due to Cryptococcus neoformans have been described since Busse and Buschke separately presented descriptions of clinical findings in the same patient. In addition cryptococcal disease has been noted to occur in a wide variety of mammals.1 Although epizootics of bovine cryptococcal mastitis have occurred2 , 3 none of the human infections have been closely associated with each other both chronologically and geographically. This report describes an unusual occurrence of 3 cases in human beings that were apparently related in both time and place.On February 13, 1959, the first patient, a retired farmer from Kingfisher, Oklahoma, . . .