Key result
Angiopoietin-like 4 (ANGPTL4) coordinates an increase in cellular energy flux crucial for epithelial-mesenchymal transition and metastasis via the ANGPTL4/14-3-3γ signaling axis.
Why the study?
Does ANGPTL4 knockdown reduce cancer metastasis and EMT in preclinical models?
Does ANGPTL4 knockdown reduce cancer metastasis and EMT in preclinical models?
ANGPTL4 coordinates cellular energy flux crucial for EMT and metastasis via the 14-3-3γ signaling axis, presenting a potential therapeutic target for metastatic cancer.
No takes yet. Share an insight, caveat, or question.
May inform metabolic targeting in metastasis; leaves open clinical validation of glucose-driven EMT.
Teo et al. (2017) studied Metastatic cancer. ANGPTL4 modulation vs. Control (ANGPTL4 deficiency or vehicle) was evaluated on Cellular energy charge and epithelial-mesenchymal transition (EMT) competency. Angiopoietin-like 4 (ANGPTL4) coordinates an increase in cellular energy flux crucial for epithelial-mesenchymal transition and metastasis via the ANGPTL4/14-3-3γ signaling axis.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: