Design, synthesis, anti-proliferative evaluation and docking studies of 1 H -1,2,3-triazole tethered ospemifene–isatin conjugates as selective estrogen receptor modulators

A library of 1 H -1,2,3-triazole-tethered ospemifene–isatin and ospemifene–spiroisatin conjugates have been synthesized and evaluated for their anti-proliferative activities against MCF-7 and MDA-MB-231 cell lines.