Key result
The human MAP-1B gene maps to chromosome 5q13 and shows tight genetic linkage to spinal muscular atrophy mutations, with a maximum lod score of +20.24.
Effect estimate: lod score +20.24
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Implicates MAP-1B as SMA candidate; leaves open causal confirmation pending mutation studies.
Lien et al. (1991) studied Spinal muscular atrophy (n=43). MAP-1B gene locus was evaluated on Genetic linkage (lod score) between SMA and MAP-1B (lod score +20.24). The human MAP-1B gene maps to chromosome 5q13 and shows tight genetic linkage to spinal muscular atrophy mutations, with a maximum lod score of +20.24.
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