Key result
Polymorphisms of UCP2 and UCP3 genes are associated with energy dissipation, fat metabolism, obesity, and diabetes in humans.
This review highlights the potential role of UCP2 and UCP3 gene polymorphisms in energy homeostasis, obesity, and diabetes.
Supports genetic associations with obesity and diabetes; leaves open causal mechanisms and therapeutic implications of UCP2/UCP3 variants.
Uncoupling proteins (UCPs) belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. In mammals, more than five family members have been identified, including UCP1, UCP2, UCP3, UCP4 (or BMCP1/UCP5) and UCP5. The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity. Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolism, obesity and diabetes. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans.
No takes yet. Share an insight, caveat, or question.
Jia et al. (2009) conducted a review in Fat metabolism, obesity, and diabetes. Polymorphisms of UCP2 and UCP3 genes was evaluated. Polymorphisms of UCP2 and UCP3 genes are associated with energy dissipation, fat metabolism, obesity, and diabetes in humans.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: