OBJECTIVE: The objective of this study was to understand whether histone deacetylase (HDACs) inhibitor Trichostatin A or TSA can block and/or reverse chronic alcohol exposure-induced ROS in human monocyte-derived dendritic cells (MDDCs). Additionally, since nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a known regulator of antioxidant responses, we studied the effects of alcohol and TSA on ROS production and modulation of Nrf2 by MDDCs. METHODS: using the GeneMania prediction server. RESULTS: gene expression was significantly enhanced by TSA. CONCLUSION: ; however, further studies are needed to fully understand the molecular mechanisms.
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Parira et al. (2018) studied this question.
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