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Case report reveals 18F-PSMA-1007 uptake in bladder urothelial carcinoma and osteoblastic metastases, indicating that PSMA-targeted imaging can detect non-prostate tumor vasculature.
Background: PSMA PET can accurately localize PSMA-expressing lesions. However, PSMA expression is not limited to prostate cancer cells but is also widely present in the neovascular endothelial cells of various solid tumors. Case presentation: We present a case of urothelial carcinoma of the bladder with multiple bone metastases. Conclusions: This case highlights that ¹⁸F-PSMA-1007 PET/CT improved visualization of the primary bladder lesion, and demonstrates that ¹⁸F-PSMA-1007–avid osteoblastic bone metastases can originate from bladder cancer.
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Wang et al. (2026) studied this question.
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