MHC Class II restricted epitope prediction, crypticity analysis and B cell epitope identification from the proteome of Leishmania donovani

Q: What does this research mean for the field?

Specific MHC Class II restricted and B cell epitopes predicted from the Leishmania donovani proteome exhibit cryptic behavior and may be important for eliciting a humoral immune response. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Mohammad Kashif; Shweta Sargam; Naidu Subbarao; Partha Pratim Manna

doi:10.1080/07391102.2026.2725805

September 3, 2026Journal of Biomolecular Structure and DynamicsOpen Access

MHC Class II restricted epitope prediction, crypticity analysis and B cell epitope identification from the proteome of Leishmania donovani

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Key Points

To predict MHC class II-restricted epitopes, analyze their cryptic characteristics, and identify potential B cell epitopes within the Leishmania donovani proteome.
Screened the proteome of Leishmania donovani using computational prediction tools to identify MHC class II-restricted epitopes and evaluate crypticity relative to native peptides.
Identified linear and conformational B cell epitopes to map target residues involved in eliciting humoral immunity.
Predicted peptides demonstrated altered binding values compared to original sequences, indicating cryptic behavior among MHC class II epitopes.
Characterized linear and conformational B cell epitopes, highlighting key residues likely responsible for driving protective humoral immune responses.

Implication

Computational analysis identifies cryptic MHC class II and B cell epitopes in Leishmania donovani, suggesting targets for eliciting humoral immune responses.

Abstract

values than the original peptides, suggesting cryptic behaviour of the epitopes. Linear and conformation B cell epitopes were also predicted which may suggest importance of these residues for eliciting humoral response.

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Cite This Study

Kashif et al. (2026) studied this question.

synapsesocial.com/papers/6a9d1df228139818eab20b30 https://doi.org/10.1080/07391102.2026.2725805

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MHC Class II restricted epitope prediction, crypticity analysis and B cell epitope identification from the proteome of Leishmania donovani

Key Points

Implication

Abstract

Discussion

Cite This Study

MHC Class II restricted epitope prediction, crypticity analysis and B cell epitope identification from the proteome of Leishmania donovani

Key Points

Implication

Abstract

Discussion

Cite This Study

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