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Systematic review uncovers mortality awareness and subsequent meaning reconstruction in adult cancer survivors, highlighting the need for existentially informed psychosocial care.
Cancer survivorship frequently involves confrontation with mortality, yet qualitative findings on meaning-making and existential experiences remain fragmented. This PRISMA 2020-guided systematic review synthesized qualitative evidence on meaning-making among adult cancer survivors across Scopus, Web of Science, MEDLINE, and the Psychology & Behavioral Science Collection (final search: 25 November 2025). Twenty-eight qualitative studies were included and synthesized using thematic synthesis, with confidence assessed via GRADE-CERQual. Five themes were identified: confrontation with mortality and existential shock; existential suffering and biographical disruption; meaning reconstruction and reorientation; transcendence, spirituality, and faith-based meaning; and psychological adaptation, resilience, and growth. Across diverse cultural contexts, cancer survivorship consistently involved mortality awareness and existential destabilization, followed by efforts to restore coherence and purpose. Spirituality, self-transcendence, and resilience emerged as prominent coping pathways. These findings support meaning-centered and existentially informed psychosocial care with culturally sensitive spiritual resources.
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Chian et al. (2026) studied this question.
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