Recognition and Treatment of Sleep Disturbances in Cancer

various established interventions, risks of treatment-related complications, potential risks and benefits of investigational therapies. The risk of contralateral breast cancer and its management are already part of many discussions at initial diagnosis and should be emphasized, but not overemphasized. As Graeser et al 12 have shown, knowledge of BRCA1/2 mutation status may inform this aspect of the discussion, providing reassurance to women whose genetic testing is negative and stratified information to mutation carriers on which to base some difficult decisions. While the data should further impel us to find better nonsurgical ways of preventing breast cancer in women at risk-including breast cancer survivors and women with and without inherited susceptibilities-for the moment, at least, we can provide ever more reliable and refined information with which to personalize our patients' care.