Key result
High antigliadin antibody titers were found in 44% (23 of 52) of patients with Huntington's disease, suggesting they may be an epiphenomenon in neurodegenerative diseases.
Observational (n=52)
The presence of high antigliadin antibody titers in 44% of Huntington's disease patients suggests these antibodies may be an epiphenomenon in neurodegenerative diseases rather than specific to gluten ataxia.
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Should not alter antigliadin testing in neurodegeneration; leaves open epiphenomenon as general marker.
The relevance of gluten sensitivity in sporadic and hereditary ataxia pathogenesis is unclear. The authors found high antigliadin antibody titers in 23 of 52 (44%) patients with Huntington's disease (HD), suggesting a previously unrecognized association between HD and gluten sensitivity. The results further question "gluten ataxia" as a distinct disease entity and raise the possibility that antigliadin antibodies in ataxia and other neurodegenerative diseases may be an epiphenomenon, the mechanisms of which remain to be investigated.
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Bushara et al. (2004) conducted an observational in Huntington's disease (n=52). Antigliadin antibodies was evaluated on High antigliadin antibody titers. High antigliadin antibody titers were found in 44% (23 of 52) of patients with Huntington's disease, suggesting they may be an epiphenomenon in neurodegenerative diseases.
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