Review: angiotensin converting enzyme inhibitors and angiotensin receptor blockers prevent atrial fibrillation

Healey JS, Baranchuk A, Crystal E, et al. Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis. J Am Coll Cardiol 2005;45:1832–9. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q In patients with heart failure, vascular disease, hypertension, or electrical cardioversion for atrial fibrillation (AF), do angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) prevent the development or recurrence of AF? Clinical impact ratings Internal medicine ★★★★★★☆ Cardiology ★★★★★★☆ ### ![Graphic][5] Data sources: Medline and EMBASE/Excerpta Medica (from 1980), abstracts of scientific meetings (past 4 y), reference lists of relevant articles, and contact with authors of appropriate trials that did not publish AF outcomes. ### ![Graphic][6] Study selection and assessment: randomised controlled trials (RCTs) with a parallel design, published in English, that compared an ACE inhibitor or ARB with placebo, no treatment, or an alternate … [1]: {openurl}?query=rft.jtitle%253DJournal%2Bof%2Bthe%2BAmerican%2BCollege%2Bof%2BCardiology%26rft.stitle%253DJ%2BAm%2BColl%2BCardiol%26rft.issn%253D0735-1097%26rft.aulast%253DHealey%26rft.auinit1%253DJ.%2BS.%26rft.volume%253D45%26rft.issue%253D11%26rft.spage%253D1832%26rft.epage%253D1839%26rft.atitle%253DPrevention%2Bof%2BAtrial%2BFibrillation%2BWith%2BAngiotensin-Converting%2BEnzyme%2BInhibitors%2Band%2BAngiotensin%2BReceptor%2BBlockers%253A%2BA%2BMeta-Analysis%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jacc.2004.11.070%26rft_id%253Dinfo%253Apmid%252F15936615%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/j.jacc.2004.11.070&link_type=DOI [3]: /lookup/external-ref?access_num=15936615&link_type=MED&atom=%2Febmed%2F11%2F1%2F15.atom [4]: /lookup/external-ref?access_num=000229593000018&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif