May 26, 2009American Journal of Hematology
Acute weight gain and diastolic dysfunction as a potent risk complex for post stem cell transplant atrial fibrillation
Key result
Weight gain of ≥7% in the first week post-transplant (HR 3.68; P=0.0120) and baseline diastolic dysfunction (HR 2.294; P=0.0082) independently predicted first atrial fibrillation or flutter.
Why the study?
What are the incidence and risk factors for atrial fibrillation/flutter following stem cell transplant in multiple myeloma patients?
Population
n=383 multiple myeloma patients consecutively undergoing stem cell transplant with no history of atrial…
Comparison
Stem cell transplant and assessment of risk… vs Age and sex-matched multiple myeloma patients…
Design
Cohort
Follow-up
1,002 person-years
Authors
Discussion
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Implication
May support early fluid monitoring and pre-transplant diastolic assessment in multiple myeloma; hypothesis-generating for arrhythmia prevention trials.
Study Design
Type
Cohort (n=383)
Multicenter
No
Structured PICO
What are the incidence and risk factors for atrial fibrillation/flutter following stem cell transplant in multiple myeloma patients?
P
Population
383 multiple myeloma patients without prior atrial fibrillation or flutter undergoing stem cell transplant, followed for a total of 1,002 person-years.
E
Exposure
Stem cell transplant (SCTX) and assessment of risk factors (weight gain ≥7% in 1st week post-SCTX, diastolic dysfunction)
C
Comparator
Age and sex-matched multiple myeloma patients without stem cell transplant
O
Outcome
First atrial fibrillation (AF) or flutterhard clinical
Main Result
Hazard Ratio: 3.68
p-value: p=0.0120
Stem cell transplant in multiple myeloma patients is associated with an increased risk of early atrial fibrillation or flutter, which is strongly predicted by acute post-procedural weight gain and baseline diastolic dysfunction.
Cite This Study
Fatema et al. (2009) conducted a cohort in Multiple myeloma (n=383). Weight gain ≥7% in the first week post-transplant and diastolic dysfunction vs. Absence of these risk factors was evaluated on First atrial fibrillation/flutter (HR 3.68, p=0.0120). Weight gain of ≥7% in the first week post-transplant (HR 3.68; P=0.0120) and baseline diastolic dysfunction (HR 2.294; P=0.0082) independently predicted first atrial fibrillation or flutter.